Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome

Ataman, Oleksandr Vasylovych; Harbuzova, Viktoriia Yuriivna; Obukhova, Olha Anatoliivna; Dubovyk, Yevhen Ivanovych

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Title	Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome
Authors	Ataman, Oleksandr Vasylovych Harbuzova, Viktoriia Yuriivna Obukhova, Olha Anatoliivna Dubovyk, Yevhen Ivanovych
ORCID	http://orcid.org/0000-0002-1941-740X http://orcid.org/0000-0001-7183-6997 http://orcid.org/0000-0002-2104-8412 http://orcid.org/0000-0002-6720-8397
Keywords	ектонуклеотид пірофофотази/фосфодіестерази 1 эктонуклеотид пирофофотазы/фосфодиестеразы 1 ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) гострий коронарний синдром острый коронарный синдром acute coronary syndrome поодинокий поліморфізм однонуклеотидный пориморфизм single nucleotide polymorphism фактори ризику факторы риска risk factors
Type	Article
Date of Issue	2018
URI	https://essuir.sumdu.edu.ua/handle/123456789/80865
Publisher	Springer
License	In Copyright
Citation	Ataman, A.V., Harbuzova, V.Y., Obukhova, O.A. et al. Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome. Cytol. Genet. 52, 127–131 (2018). https://doi.org/10.3103/S0095452718020020
Abstract	The present study was performed to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with the known risk factors of atherosclerosis (overweight, dyslipoproteinemia, hypertension, diabetes, smoking, and hypercoagulability) in persons with acute coronary syndrome. Venous blood of 118 patients was genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. In patients divided into two subgroups according to their genotype (KK and KQ + QQ), the statistically significant differences were revealed only for plasma LDL-cholesterol level and fibrinolytic activity. The carriers of minor allele (KQ + QQ) had lower LDL-cholesterol concentration and the time of fibrinolysis than the major allele homozygotes (KK). The division of patients into subgroups according to presence or absence of some risk factors for atherosclerosis showed no statistically significant differences between K121Q genotype distributions for any of the comparison.
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