Prostate cancer leads to a change in the composition of tissue carbohydrates

Romaniuk, Anatolii Mykolaiovych; Piddubnyi, Artem Mykhailovych; Lyndin, Mykola Serhiiovych; Sikora, Vladyslav Volodymyrovych; Hyriavenko, Nataliia Ivanivna; Moskalenko, Roman Andriiovych

Please use this identifier to cite or link to this item: http://essuir.sumdu.edu.ua/handle/123456789/75111

Or use following links to share this resource in social networks: Recommend this item

Title	Prostate cancer leads to a change in the composition of tissue carbohydrates
Authors	Romaniuk, Anatolii Mykolaiovych Piddubnyi, Artem Mykhailovych Lyndin, Mykola Serhiiovych Sikora, Vladyslav Volodymyrovych Hyriavenko, Nataliia Ivanivna Moskalenko, Roman Andriiovych
ORCID	http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-4147-6879 http://orcid.org/0000-0002-9805-014X http://orcid.org/0000-0002-2342-0337
Keywords	рак передміхурової залози рак предстательной железы prostate cancer вуглеводи углеводы carbohydrates PAS гістохімія гистохимия histochemistry
Type	Conference Papers
Date of Issue	2019
URI	http://essuir.sumdu.edu.ua/handle/123456789/75111
Publisher	Springer
License
Citation	Prostate cancer leads to a change in the composition of tissue carbohydrates / A. Romaniuk, A. Piddubnyi, M. Lyndin et al. // Virchows Archiv. European Journal of Pathology. – 2019. – Vol. 475, Suppl 1. – S. 25. – Pathology: Path to Precision medicine : 31th European Congress of Pathology, 7–11 September 2019, Nice, France.
Abstract	The objective of the investigation is following - to study the changes in the composition of the carbohydrate components of prostate cancer tissue (PCa). Methods: 60 PCa samples (30 samples of PCa with intraluminal inclusions (prostatic calculi and corpora amylacea) and 30 without them) were used for study. 20 samples of benign prostatic hyperplasia tissue were used as control. All samples were examined by hematoxylin-eosin staining and by histochemistry (PAS reaction, alcian blue staining at pH 2.5). Results: Positive PAS staining was found both in the tissue of the prostate gland and in the secret. Strongest intensity of the signal was found in glands filled by secret. Corpora amylacea and the secret of the PCa glands were PAS-negative. BPH tissue had a weak alcian blue staining intensity. The secret of PCa glands was very positive for alcian blue staining. We indicate the presence of higher amount of acid mucopolysaccharides in the connective tissue component of PCa. Conclusion: Changes in the carbohydrate composition of the prostate tissue during carcinogenesis were found. It manifests in reduced amount of glycosaminoglycans and increased amount of acid mucopolysaccharides in both the secret of the glands and the tumour tissue.
Appears in Collections:	Наукові видання (НН МІ)