Generation and Collection of Biological Nanoaerosols

Abstract

The report describes new technologies in generation and collection of biological nanoaerosol (NA) developed in the laboratory of Nanostructures and Nanotechnologies, ITEB RAS. NA generator to be used for pulmonary delivery of antibiotics, anti-inflammatory and other drugs and vaccines employs a new atomization principle based on a gas-phase neutralization of electrospray-generated drug nanoclusters with small counter-ions produced by electrospraying of a volatile solvent like ethanol. It was demonstrated that a variety of biological substances including proteins can be atomized into NA of 20-100 nm in size, using this generator without affecting functional properties of the atomized substance. Several approaches have been developed to measure doses of inhaled NA including standard condensation particle counter, quartz resonator and filters from polyvinylpirrolidone nanofibers. It was demonstrated that water-soluble electrospun nanofilters may also be employed to capture pathogens and pathogen biomarkers for analysis of nosocomial infections in clinics wards, in collection of non-volatile biomarkers in the exhaled breath, in testing working places for NA pollution and in other applications. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35432